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Figure 1 Mean Change from Baseline in PCWP and RAPs
(Top) Mean change from baseline in pulmonary capillary wedge pressure (PCWP) out to 8 h after treatment administration. The pairwise comparisons of 15, 30, and 60 mg tolvaptan versus placebo each showed a statistically significant decrease in peak change in PCWP from 3 to 8 h post-dose, the pre-specified time period for assessment. (Bottom) Mean change from baseline in right atrial pressure (RAP) in the 4 treatment groups. The tolvaptan 15- and 30-mg doses resulted in statistically significant reductions in peak change in RAP as compared with placebo.
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