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Figure 1 CHGA Common Haplotypes and BP in the Population
(A) Chromogranin A (CHGA) polymorphisms in individuals from population blood pressure (BP) extremes: haplotype sliding-window analysis. Four common variants (each minor allele frequency  8%) (Table 1) were scored to span the CHGA locus. The exon/intron structure of the locus, as well as the positions for all common single nucleotide polymorphisms (SNPs) (21), is depicted in the schematic at the bottom. Results for haplotypes composed of 1, 2, 3, or 4 SNPs were computed by the SNP expectation maximization algorithm for the dichotomous BP trait, and significance is plotted as reciprocal p values for each group: all subjects (left), men only (center), and women only (right). The p values were derived from omnibus permutation tests. Significant (<0.05) p values are shown at the appropriate point. (B)
CHGA common extended haplotype GGCC: sex-dependent effect on BP as a quantitative trait in population BP extremes. Extended 4-SNP haplotype GGCC is the most common haplotype in this population (at 57.4% of chromosomes; see inset). The effect of haplotype GGCC on the quantitative trait diastolic blood pressure (DBP) is illustrated separately for men and women. There is a significant overall effect for genotype (p = 0.023), as well as an effect in men alone (p = 0.006).
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