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Figure 7 Serial Sections Showing a Rabbit Atherosclerotic Plaque at 28 Days After PDT Treatment
Photodynamic therapy (PDT) simultaneously reduced macrophages (A and F) and replaced existing plaque matrix with quiescent smooth muscle cells (B and G) in the non-G2 or S phases (C and H) as indicated by the Ki67 cell proliferation marker. After endothelial denudation of all rabbit arteries, staining with Factor VIII revealed the presence of endothelium in PDT-treated arteries and controls (D and J) indicative of arterial repair by 28 days. Panels E and K show the presence of the internal elastic membrane and external elastic membrane with Movat's stain. Note that plaque area is significantly less than controls at 28 days after PDT. Magnification x200.
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