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Figure 5 CH Inhibited GTN-Induced CGRP Expression
Peripheral blood monuclear cells (PBMCs) from ALDH2*1/*1 homozygotes were seeded in the presence of GTN (10–5 mol/l) for 24 h with or without 1 mmol/l chloral hydrate (CH) pre-treatment (control group; GTN group: 10–5 mol/l GTN; GTN+CH group: 10–5 mol/l GTN+1 mmol/l CH; CH group: 1 mmol/l CH). The CGRP I and CGRP II mRNA expression in PBMCs was analyzed by real-time polymerase chain reaction and expressed as percentage of control (mean ± SEM, n = 3, respectively). *p < 0.05 compared with control. #p < 0.05 compared with corresponding GTN group. Abbreviations as in Figures 1, 2, and 4.
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