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Figure 1 Changes in Blood Pressure and Heart Rate After GTN Administration
Variation of SBP (A), DBP (B), HR (C), absolute decrease from baseline in SBP ( SBP) (D) and DBP (DBP) (E), and absolute increase from baseline in HR (HR) (F) in response to sublingual GTN administration in ALDH2*1/*1 homozygotes (solid circles; n = 9) and carriers of ALDH2*2 allele (open circles; n = 9). Values are mean ± SEM. *p < 0.05, #p < 0.01, **p < 0.001 compared with corresponding time point of carriers of ALDH2*2 allele. ALDH2 = mitochondrial aldehyde dehydrogenase-2; DBP = diastolic blood pressure; GTN = glyceryl trinitrate; HR = heart rate; SBP = systolic blood pressure.
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