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Figure 6 Infused FBF in Subjects During Infusion
Infused FBF in subjects during infusion of (top row) (Pyr1)apelin-13 in the presence (solid squares) or absence (open squares) of nitric oxide (NO) clamp (left) or aspirin (right) and (bottom row) acetylcholine in the presence (solid circles) or absence (open circles) of NO clamp (left) or aspirin (right). p < 0.0001; 1-way ANOVA for dose responses to (Pyr1)apelin-13 and acetylcholine alone. For placebo versus NO clamp (AUC): (Pyr1)apelin-13, p < 0.01; acetylcholine, p < 0.05. For placebo versus aspirin (AUC): (Pyr1)apelin-13, p = 0.7; acetylcholine, p = 0.9. AUC = area under the curve; other abbreviations as in Figure 3.
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