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Figure 7 Effect of CD-NP on cGMP Generation and Antiproliferative Actions of CD-NP in Human CFs
(A) Cyclic 3'5' guanosine monophosphate (cGMP) generation in human cardiac fibroblasts (CFs). Data are expressed as means ± SE. *p < 0.05 versus no treatment; **p < 0.05 versus CP-NP 10–11M; +p < 0.05 versus CD-NP 10–8 M. (B) Antiproliferative actions of CD-NP in human CFs. Bar graph reports colormetric bromodeoxyuridine (BrdU) uptake in optical density units as measured by colorimetry. Data are expressed as means ± standard error. *p < 0.05 versus control. Cardiotrophin-1 = proliferation of fibroblasts by cardiotrophin-1; Cardiotrophin-1 + CD-NP = CD-NP added to cardiotrophin-1 stimulated fibroblasts; Control = untreated human cardiac fibroblasts.
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