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Figure 3 Immunoblotting Studies for Characterization of Cell Adhesion Complex Proteins
(Top) Representative Western blots of tissue obtained from infarct rupture patients and control myocardial infarction (MI) patients, both from remote (nonischemic) and infarct areas. (A)  E-catenin, (B) β-catenin, (C)  -catenin, and (D) N-cadherin; -tubulin was used for normalization of the samples. (Bottom) Quantitative analysis of adhesion complex proteins, expressed as protein/-tubulin ratio. Significantly less E-catenin was detected in the remote area of infarct rupture patients (n = 10) compared with that seen in control MI patients (n = 10). In the infarct area, E-catenin was undetectable in the infarct rupture group but readily detectable in the control MI group. Similar levels of β-catenin, -catenin, and N-cadherin were observed in the remote areas of infarct rupture and control MI groups, although more extensive degradation of these proteins was detected under ischemic conditions. *p < 0.01; **p < 0.001; #p < 0.05.
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