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Figure 5 Vascular Changes Due to Overexpression of Mutant Amyloid Precursor Protein
Compared with normal cerebral vascular anatomy and flow dynamics in 10-month-old wild mice (A), magnetic resonance angiography shows minor flow voids (arrow) in 6-month-old mice overexpressing a mutant form of amyloid precursor protein (APP23) with fairly preserved structures on corrosion casts (B). Twenty-month-old APP23 mice display significant flow abnormalities, including partial and complete flow voids (C). The corresponding corrosion cast demonstrates constriction, inclusions, and vessel elimination (D). Also noteworthy is the presence of a small artery connecting the left and the right sides of the circle of Willis (# in panels C and D) likely to maintain a dimunitive level of blood flow under the circumstance of vessel substitution at the posterior cerebral artery level. Images used with permission of the Society of Neuroscience (39).
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