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Figure 3 Ubiquitin Expression and Proteasome Activity in Advanced Atherosclerosis
Increase in ubiquitin immunoreactivity in complicated plaques of fatal acute myocardial infarction-related coronary arteries compared with advanced plaques in the noninfarction-related coronary arteries of the same patient, relating to differences in the shoulder and fibrous cap areas (left). Images on the left and data for the bottom left graph adapted, with permission, from Herrmann et al. (17). In carotid artery plaques of patients with symptoms of transient ischemic attack (TIA), stroke, or amaurosis (Am.) fugax, the level of ubiquitin-protein conjugates, but not of free ubiquitin, is higher and proteasome function is lower than in carotid plaques from asymptomatic patients (right). Graphs on the right used with permission of the American Heart Association (19).
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