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Figure 6 Effects of Post-Exposure Plasma and Cotinine on EPCs In Vitro
Plasma isolated after SHS exposure and pure cotinine decrease chemotaxis to VEGF (A), increase proliferation (B), and increase random cell movement (C) similar to NO synthase inhibition with L-NMMA. The EPCs were isolated from nonexposed subjects (n = 6) and incubated with L-NMMA, plasma isolated before (B, baseline), immediately after (0 h), and 24 h after SHS exposure. Right sides of graphs represent cotinine dose response. Dashed lines show plasma cotinine range after SHS exposure (approximately 0 to 1 ng/ ml). *p < 0.05 versus control. #p < 0.05 versus baseline plasma. L-NMMA = LG-monomethyl-arginine; other abbreviations as in Figures 1 and 3.
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