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Figure 8 Semiquantification of HIF Pathway Immunoreactivity in Carotid Atherosclerosis
(A) Immunoreactivity of HIF pathway proteins was significantly increased from early (green bars, n = 5) to stable lesions (white bars, n = 5) for HIF1 , HIF2, VEGF, GLUT1, and GLUT3 but similar in stable and thrombus-containing lesions (blue bars, n = 5). *p < 0.05 versus early; **p < 0.01 versus early. (B) Macrophages in advanced lesions demonstrated strong immunoreactivity of HIF-responsive genes: VEGF (B), GLUT3 (C), and HK1 (D). (E) Microvessel density was determined in 6 human carotid arteries with early (intimal thickening), 6 stable, or 5 thrombus-containing atherosclerotic lesions. *p < 0.01 versus early. L = lumen; other abbreviations as in Figures 2 and 7.
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