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Figure 5 Immunoreactivity of HIF Pathway in Nondiseased and Atherosclerotic Carotid Artery

Nuclear staining of HIF1 ${alpha}$ (A to D) and HIF2 ${alpha}$ (E to H) is absent in the human mammary artery (A and E, respectively) and increased from early (B and F, respectively) to advanced carotid lesions (C and G, respectively). Macrophages in advanced lesions demonstrated strong HIF1 ${alpha}$ (D) and HIF2 ${alpha}$ (H) expression. Nuclear immunoreactivity (functional protein levels) of HIF1 ${alpha}$ and HIF2 ${alpha}$ are similar. Abbreviations as in Figures 1 and 2.

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