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Figure 2 Hypoxia Colocalizes With CD68, HIF, and VEGF
(A) Hypoxia detected by pimonidazole immunoreactivity in human carotid atherosclerosis. Serial sections show colocalization with CD68-positive macrophages (B), HIF1 (C), and VEGF (D). (E) The immunoreactivity score of CD68, HIF1, and VEGF is increased when hypoxia is present (solid bars) versus absent (open bars) in human carotid atherosclerosis (*p < 0.05). HIF = hypoxia-inducible transcription factor; VEGF = vascular endothelial growth factor.
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