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Figure 3 Statin Treatment Reduces Rac1 Activity in RacET Mice
(A) Rac1-GTPase activity determined by GST–p21-activated kinase (PAK) pull-down assays in WT, 10-month-old RacET mice (RacET10), and RacET10 treated with rosuvastatin 0.4 mg/d orally for 10 months (RacET10 + statin), n = 8, *p < 0.05 versus RacET10. (B) Representative Western blots and (C) quantification of Rac1 GTPase expression (total protein, membrane, and cytsolic fraction) related to ß-actin in RacET10 and RacET10 + statin, n = 6, *p < 0.05 versus RacET10. (D) Representative M-mode echocardiographic images of the LV of RacET10 and RacET10 + statin. Quantification of measurements of (E) FS; (F) IVSd; (G) LPWd; and (H) LVDd; n = 8, 5 to 8 separate measurements/animal; *p < 0.05. Abbreviations as in Figure 1.
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