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Figure 1 RacET Mice Develop Atrial Dilatation and Atrial Fibrillation
(A) Representative cross sections of the left ventricle (LV), and (B) M-mode echocardiographic images of the LV of wild-type (WT), transgenic mice with cardiac overexpression of Rac1 GTPase (RacET)16, and transaortic constriction (TAC)16 mice. Quantification of measurements of (C) fractional shortening (FS); (D) diastolic interventricular septum (IVSd); (E) diastolic left posterior wall (LPWd); and (F) left ventricular end-diastolic diameter (LVDd); n = 6, 5 separate measurements/animal. (G) Ratio of weight of atria to total heart and tibia length. (H) Incidence of atrial fibrillation (AF), and (I) representative electrocardiography recording. n = 10, *p < 0.05 compared with WT.
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