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Figure 1 Atherosclerotic Lesions Are Reduced by CD31Rg Treatment
(Micrographs) Representative micrographs of MT-stained sections (original magnification 40x). Myocardiocytes are stained red, elastin fibers and nuclei appear black, extracellular matrix appears green. Fibrofatty atherosclerotic lesions are present in the 3 aortic cups in PBS and CD31Rg  1-2 groups, whereas they are limited to 2 of the 3 cusps by CD31Rg treatment. Adventitial inflammation was reduced in the CD31Rg group (white arrows). (Bottom right panel) Morphometric analysis was performed at 200, 400, 600, and 800 µm from the appearance of the first aortic cusp, starting from the ventricular side of the aortic root, by oil-red O staining and computer-assisted image analysis. The CD31Rg-treated group showed significantly smaller lesions as compared to the CD31Rg 1-2 and PBS control groups. *p < 0.01 versus CD31Rg 1-2 and PBS, n = 14 mice/group. CD31Rg = CD31 receptor globulin; CD31Rg 1-2= truncated CD31 receptor globulin lacking domain 1-2; MT = Masson’s trichrome staining; PBS = phosphate-buffered saline.
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