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Figure 5 Hemodynamic Effect of S16E Gene Delivery on the Failing Heart
Echocardiographic and hemodynamic effects of AdS16EPLN (n = 9) gene transfer to the failing ovine heart compared with AdLacZ (lacZ) (n = 6) treated animals. (A) Left ventricular (LV) ejection fraction; (B) LV end-diastolic area;(C) LV end-diastolic pressure (EDP); (D) Peak positive dP/dt. Solid bars = before gene delivery; open bars = 2 weeks after gene delivery. AdLacZ = adenovirus ß-galactosidase; AdS16EPLN = adenovirus serine-to-glutamate "pseudo-phosphorylated" phospholamban mutant.
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