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Figure 2 Recombinant Human Antibodies to MDA–apoB-100 Peptides Upregulate ABCA-1 Expression In Vivo and In Vitro
(A) ABCA-1 staining of aortic arch plaques from FITC-8–, IEI-E3–, and 2D03-treated mice. (B) The values represent the percentages of ABCA-1–stained area per total plaque area. (C) Flow cytometry histogram showing ABCA-1 expression of untreated (gray shaded peak), FITC-8–treated (black line overlay), and 2D03-treated (red line overlay) cells. (D) Mean ABCA-1 expression of untreated and FITC-8– and 2D03-treated cells. The values are expressed as percentages of mean fluorescent intensity of the untreated control. Scale bar = 100 µm. *p < 0.02 and **p < 0.01 versus FITC-8. ABCA-1 = adenosine triphosphate–binding cassette transporter A1; apoB-100 = apolipoprotein B-100; FITC-8 = fluorescein isothiocyanate-8; MDA = malondialdehyde.
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