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Figure 4 Immunohistochemical Analyses Showing the Sarcolemmal Staining Pattern for Dystrophin Using Antidystrophin Antibody
Dystrophin pattern was conserved in cardiac tissue sections of (A) healthy heart controls (immunostaining in red) and of (B) enterovirus (EV)-negative patients who died of acute myocardial infarction (immunostaining in red). Example of focal areas of myocardium displaying a loss of the sarcolemmal staining pattern in cardiac tissue sections of EV-positive patients (B and E, arrows). In several study cases, immunohistochemical analyses of serial cardiac sections demonstrated that there was focal disruption of the sarcolemmal organization of dystrophin (F, arrows) in the same areas of cardiac tissue that were positive for the EV capsid viral protein 1 (C, arrows) (immunostaining in brown). The sections were counterstained with hematoxylin. Magnification: x400 (A and B); x1,000 (C to F).
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