Please click here to obtain permission to reproduce this image.
Click on image to view larger version.
Figure 2 SNPs, Tag SNPs, and Microsatellites as Genomic Markers
(A) Autologous chromosome with evenly spaced microsatellites. (B) Segment of deoxyribonucleic acid (DNA) between microsatellite markers. Single nucleotide polymorphisms (SNPs) are noted (A,B,C...) within the DNA segment. Tag SNPs (C,H,K) travel with other noted SNPs as blocks (haplotypes) and can serve as a surrogate for these haplotypes and, more importantly, disease-causing genes in close proximity. (C) A DNA segment with alternative alleles and genomic markers of the same genes designated in part B of the figure. Note that the microsatellite markers are not as close in proximity to the genes as the noted SNPs.
|
