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J Am Coll Cardiol, 2007; 50:1911, doi:10.1016/j.jacc.2007.07.049 (Published online 22 October 2007).
© 2007 by the American College of Cardiology Foundation
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CORRESPONDENCE: LETTER TO THE EDITOR

Coenzyme Q10 in Statin-Associated Myopathy

Harvey Wolinsky, MD, PhD, FACC*

* Clinical Professor of Medicine, Mt. Sinai Medical Center, Department of Medicine, 49 East 96th Street, Suite 1A, New York, New York 10128 (Email: HWolinskymd{at}aol.com).

The excellent review by Macroff and Thompson titled "The role of coenzyme Q10 on statin-associated myopathy" (1) concludes that insufficient evidence exists for supplementation to treat or prevent myopathy.

However, the authors recommend its use "if only via placebo effect." Should we not first be certain that statin-induced inhibition of the farnesyl (and dolichol) pathways does not contribute to the many pleiotropic benefits of statins before we attempt to "correct" them?


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  1. Marcoff L, Thompson PD. The role of coenzyme Q10 in statin-associated myopathy: a systematic review J Am Coll Cardiol 2007;49:2231-2237.[Abstract/Free Full Text]



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