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Figure 2 CD4⁺CD28^null T-Cell Frequencies in Different Groups

Frequencies of CD4⁺CD28^null T cells were determined by 2-color flow-cytometry. (A) The unstable angina (UA) patients were subgrouped according to the occurrence of both prior and further events during the 48 months of study observation. Group 1: 51 patients with the first-ever event; group 2: 30 patients with myocardial infarction and/or UA during the 24 months before study enrollment; group 3: 39 patients with further events during the 24 months of follow-up (death, myocardial infarction, UA), the majority of whom (85%) also had prior events; group 4: 67 patients with chronic stable effort angina (CSA). The CD4⁺CD28^null T-cell frequency was significantly higher in group 3 than in the other groups (p < 0.001; Kruskal-Wallis test). (B) The UA patients were subgrouped according to the occurrence of events (none versus 2 or more) during the 24 months before the study enrollment independently of the prospective outcome. CD4⁺CD28^null T-cell frequency was significantly higher in 63 patients with previous events than in 57 patients without previous events (p = 0.006). Data are presented as single data points. The dashed lines indicate CD4⁺CD28^null T-cell frequencies 4% (90th percentile of distribution in 100 age-matched healthy subjects) and >10% (10-fold higher than the median value in healthy subjects). Blue, green, and red dots indicate patients with CD4⁺CD28^null T-cell frequencies <4%, 4% to 10%, and >10%, respectively.

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