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Figure 1 Histologic and Ultrastructural Analysis of Maternally Inherited Mitochondrial Cardiomyopathy
(A) Left ventricular section obtained from a 23-year-old patient (patient 3). Cardiac myocyte hypertrophy is associated with prominent perinuclear vacuolization (hematoxylin and eosin, x20). (B) The vacuoles contain granular material that stains with periodic acid Schiff (arrows, x40). (C) Ultrastructural analysis reveals patchy areas characterized by absence of myofibrils and accumulation of osmiophilic granular and fibrillar material consistent with glycogen (uracyl acetate lead citrate, x3,150). (D) Proliferation of polymorphic mitochondria causes displacement of sarcomere. Note a giant mitochondria (arrow; uracyl acetate lead citrate, x5,000).
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