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Figure 2 Calcineurin Activity in Cardiac Myocytes With LPS and/or Ang II Inhibited by Losartan
Calcineurin activity in cardiac myocytes (mean + SE, n = 6) increased after 16-h incubation with lipopolysaccharide (LPS) (10 ng/ml) and/or angiotensin II (Ang II) (100 nmol/l) without cumulative effects (p < 0.05). This was blocked by pre-treating myocytes with losartan (1 µmol/l, Ang II type 1 receptor inhibitor) 1 h before LPS or Ang II, while losartan alone had no effect.
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