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Figure 3 Map of the Repartition of Operated CAVS in the Western Part of France
Disease frequency was calculated for each parish by comparing the number of native cases of operated calcific aortic valve stenosis (CAVS) to the population living in the village. Population was estimated from the mean of the censuses performed in 1926, 1931, and 1936. This map shows an obvious spatial heterogeneity. Two clusters of high frequency can be described, 1 on the northern part of the map and 1 between the southern part of Nantes and La Roche-sur-Yon and between the Atlantic coast and Cholet, corresponding to a well-known isolate called "vendee-cholletaise." The letters represent parishes in which familial aggregation of the disease has been identified. From Probst et al. (3).
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