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Figure 2 Schematic Representation of Natural History of Cardiac Valve Remodeling by Interstitial Cells
Schematic summary of cardiac valve remodeling in fetal valves according to the findings of the present study. Activated/immature cell phenotypes and collagen remodeling in gestation were followed after birth by decreased cell activation and eventually, in adults, by quiescence. These cellular changes were accompanied by increased collagen fiber thickness and alignment. Thin lines = thin, immature collagen fibers; thick lines = thick, mature collagen fibers. From Aikawa et al. (1). Abbreviations as in Figure 1.
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