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Figure 1 Mechanism of Action of rNAPc2
Tissue factor/activated factor VII (TF/fVIIa) inhibition by recombinant nematode anticoagulant protein c2 (rNAPc2) involves the following steps: 1) rNAPc2 binds tightly to zymogen factor X; 2) docking of the rNAPc2-fX complex to TF/fVIIa assembled on a procoagulant phospholipid surface; and 3) presentation of the reactive loop of rNAPc2 to the active site of fVIIa, resulting in a tightly bound quarternary inhibitory complex. c2 = rNAPc2; TF = tissue factor; VIIa = fVIIa; X = factor X.
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