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Figure 2 Diagram Illustrating Molecules Critical to Angiogenesis and Potential Therapeutic Targets
The scheme highlights the ability of growth factors to positively regulate the "angiogenic switch" to stimulate new vessel formation. Vessel stabilization is mediated by a coordinated response involving platelet-derived growth factor and receptor (PDGR/PDGFR) and angiopoietin (Ang) 1. Modified from Moulton et al. (43). BM = basement membrane; EC = endothelial cell; FGF = fibroblast growth factor; FGFR = fibroblast growth factor receptor; Ig = immunoglobulin; MMP = matrix metalloproteinase; PIGF = placenta growth factor; RGD = arginine-glycine-aspartic acid; Tie-2 = tunica internal endothelial cell kinase; VEGF = vascular endothelial growth factor; VEGFR = vascular endothelial growth factor receptor.
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