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Figure 1 Pathogeneses of the Brugada Pattern
(A) A normal surface V2 recording together with endocardial (Endo), midmyocardial (M), and epicardial (Epi) action potential (AP) recordings. (B) The development of a transmural voltage gradient between epicardium and endocardium, giving rise to a saddleback configuration in V2 (type II Brugada pattern). (C) Further transmural voltage changes producing a coved pattern in V2 (type I pattern). (D) Loss of the dome in the epicardial recording and enhanced coved pattern in V2. (E) Potential differences between polarized and adjacent depolarized cells may lead to re-entry (phase 2). ECG = electrocardiogram. Reprinted with permission from Antzelevitch (4).
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