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Figure 6 Forced eNOS S1177D Expression Improves Perfusion of Ischemic Myocardium
At day 28 (A) and day 49 (B), regional myocardial perfusion in the RCx region at rest was similar in all groups at resting heart rate (slice 1 = most proximal ischemic short-axis tissue slice, slice 4 = apex). (C) The LAD perfusion at day 28 was reduced to the same extent in all groups. (D) Myocardial perfusion of the apical ischemic area was significantly improved in the eNOS S1177D-treated hearts, as compared with control or L-NAME co-treated animals. (E) At resting heart rate and (F) at rapid atrial pacing, the LAD perfusion/RCx perfusion ratio was significantly improved in the eNOS S1177D hearts, when compared with control hearts (n = 6 for control subjects, eNOS S1177D, n = 5 for eNOS S1177D + L-NAME). Cx = circumflex coronary artery; other abbreviations as in Figure 2.
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