Please click here to obtain permission to reproduce this image.
Click on image to view larger version.
Figure 1 Olmesartan Inhibits Lesion Formation of the Aortic Valve in Hypercholesterolemic Rabbits
(A) a, d, g = control; b, e, h = hypercholesterolemic; c, f, i = hypercholesterolemic olmesartan treated. a to c = hematoxylin and eosin (H&E) staining; d to f = macrophage (RAM11) staining; g to i = osteopontin staining. Inset in b shows Oil red O staining. Insets in e and h represent positive staining at greater magnification. Arrowheads indicate aortic side of valve leaflet. Bar = 200 µm. Quantitation of Oil red O (B), macrophage (C), and osteopontin (D)-stained areas corrected for total area. A = olmesartan; Ao = aorta; V = vehicle.
|
