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Figure 1 A Schematic Diagram of the IS-5-MN Study Protocol
(A) Diagram of the study protocol to determine the effects of a 7-day isosorbide-5-mononitrate (IS-5-MN) therapy on endothelial function. (B) Diagram of the study protocol to determine the effect of vitamin C (vit C) on IS-5-MN–induced changes in endothelial function. Ach = acetylcholine; BP = blood pressure; HR = heart rate; IS-5-MN = isosorbide-5-mononitrate; L-NMMA = N-monomethyl-L-arginine; ROS = reactive oxygen species.
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