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Figure 2 Commercial BNP or NT-proBNP Assays
Commercial BNP or NT-proBNP assays utilize dual antibody systems which recognize 2 separate segments of BNP1-32 or of NT-proBNP1-76, respectively. (Left) The Roche NT-proBNP assay combines a capture antibody targeting proBNP aa 1-21 with a detection antibody recognizing proBNP aa 39-50. (Right) The Biosite Triage assay combines the monoclonal Scios 106.3 antibody, which binds somewhere in the proBNP aa 82-90 region, with the Biosite polyclonal antibody, which binds somewhere in the proBNP aa 79-108 region. Other abbreviations as in Figure 1.
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