Please click here to obtain permission to reproduce this image.
Click on image to view larger version.
Figure 1 ProBNP Processing
ProBNP is a 108-amino acid (aa) precursor protein which is cleaved by the endoprotease corin to form the bioactive 32 aa BNP peptide (referred to as BNP1-32 or as proBNP77-108) and the inert 76 aa N-terminal-proBNP peptide (proBNP1-76). Each fragment undergoes further N-terminal dipeptidase digestion, as might proBNP itself. BNP = B-type natriuretic peptide.
|
