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Figure 9 Prognostic utility of combining high-sensitivity C-reactive protein, troponin, and brain natriuretic peptide in the setting of acute coronary ischemia in the TIMI 16 and TIMI 18 clinical trials. Adapted with permission from Sabatine et al. (91). OPUS-TIMI = Orbofiban in Patients With Unstable Coronary SyndromesThrombolysis In Myocardial Infarction Trial; TACTICS = Treat Angina With Aggrastat and Determine Costs of Therapy With Invasive or Conservative Strategies.