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Figure 5 Superoxide formation in the mouse aorta evaluated by oxidative fluorescent microtopography with the oxidative fluorescent dye dihydroethidium (DHE). Representative photomicrographs of the aortic sections in mice receiving lipopolysaccharide (LPS) (A)
, 20 mg/kg naloxone pretreatment 1 h before LPS (B)
, and phosphate-buffered saline (C)
are shown. Increased superoxide production was visualized by amplified red fluorescence
in the aortic wall after LPS stimulation (A)
. In comparison, staining was much more reduced in the aorta of animals receiving naloxone pretreatment (B)
(bar
= 50 µm).
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