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Figure 4 Comparison of microarray and proteomic informatic analysis of muscle cell development in culture. Red
color denotes gene up-regulation, whereas green
color indicates down-regulation. The result shows that there is a reasonable correspondence of genes seen in microarray and proteomics. However, there are also very unique species that are differentially regulated between gene expression and protein presence. This shows that the transcriptosomic and proteomic approaches are complementary and not duplicative. DNA = deoxyribonucleic acid; GO = Gene Ontology; mRNA = messenger ribonucleic acid. Reprinted with permission from Kislinger T, Gramolini A, Pan Y, et al. Proteome dynamics during C2Cl2 myoblast differentiation. Mol Cell Proteomics 2005;4:887–901.
