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Figure 2 Prediction analysis for microarrays (PAM) classification. In the first step, PAM classification was applied to all 4 datasets separately. Very low misclassification rates were found in datasets A, B, and D for the classification of nonfailing (NF) versus dilated cardiomyopathy (DCM) samples, whereas the classification algorithm did not show any power in dataset C. In the second step, we repeated the procedure with the smallest gene signature obtained from dataset B (31 probe sets which correspond to 27 transcripts), now achieving more than 90% accuracy for classifying DCM and NF samples across all studies, including dataset C.
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