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Figure 3 rhNRG-1 improves hemodynamics after LAD ligation. Treatments with vehicle, rhNRG-1 (10 µg/kg, IV, daily for 5 days), captopril (2.5 mg/kg twice daily by gavage for the duration of the study), or the same doses of rhNRG-1 and captopril (capt.) in combination were commenced 1 week after LAD ligation, and hemodynamic studies were performed 33 weeks thereafter. Sham-operated animals (Sham) received no treatment. (A) Heart rate (HR); (B) mean arterial pressure (MAP); (C) LV pressure (LVP) at end-systole (LVESP, open bars), and end-diastole (LVEDP, filled bars); and (D) +dP/dt (open bars) and –dP/dt (filled bars), rate of contraction and relaxation, respectively (n = 10 for sham and vehicle groups; n = 20 for each of the other groups). *p < 0.05; **p < 0.01 versus vehicle; +p < 0.01 versus captopril. Other abbreviations as in Figures 1 and 2.
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