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Figure 3 (A) Systematic and early percutaneous coronary intervention (PCI) was associated with a nonsignificant reduction of death in the "stent era" studies as compared with ischemia-guided PCI (odds ratio, 0.56; 95% confidence interval [CI], 0.29 to 1.05; p = 0.07; analysis for heterogeneity was nonsignificant, p = 0.71) whereas an increase in the rate of death was observed in the "balloon era studies" (odds ratio, 1.44; 95% CI, 0.69 to 3.06; p = 0.33; the analysis for heterogeneity was nonsignificant, p = 0.74). The overall analysis showed a nonsignificant trend toward a reduction of death in favor of systematic and early PCI (odds ratio, 0.83; 95% CI, 0.52 to 1.35; p = 0.47; the analysis for heterogeneity was nonsignificant, p = 0.41). (B) Systematic and early PCI was associated with a nonsignificant reduction of death or myocardial infarction in the "stent era" studies as compared with ischemia-guided PCI (odds ratio, 0.53; 95% CI, 0.33 to 0.83; p = 0.0067; the analysis for heterogeneity was nonsignificant (p = 0.95) whereas it was found to be detrimental in the "balloon era" studies (odds ratio, 1.76; 95% CI, 0.97 to 3.21; p = 0.064; the analysis for heterogeneity was nonsignificant, p = 0.74). The overall analysis showed a nonsignificant trend toward a reduction of death or myocardial infarction in favor of systematic and early PCI (odds ratio, 0.85; 95% CI, 0.47 to 1.55; p = 0.42). The analysis for heterogeneity was significant (p = 0.062). CAPITAL-MI = Combined Angioplasty and Pharmacological Intervention Versus Thrombolytics Alone in Acute Myocardial Infarction; GRACIA-1 = Randomized trial comparing stenting within 24 h of thrombolysis versus ischemia-guided approach to thrombolyzed acute myocardial infarction with ST-segment elevation; MA = meta-analysis; PTCA = percutaneous transluminal coronary angioplasty; SIAM = Comparison of Invasive and Conservative Strategies After Treatment with Streptokinase in Acute Myocardial Infarction; TAMI = Thrombolysis and Angioplasty in Myocardial Infarction.
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