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Figure 3 (A) Time-dependent changes in plasma [K+], RR, and QT intervals during 2 h KCl infusion (left; n = 7). [K+] was significantly increased from 30 min and forward, whereas no changes were observed in the RR (blue circles) or QT (red circles) intervals. *p < 0.05 versus baseline (1-way repeated measures analysis of variance). (Right) Representative example of the electrocardiogram before and after elevation of plasma [K+]. RR and QT intervals are noted above and below lead II. LL refers to a precordial lead placed in the 6th intercostal space on the left lateral side of the thorax. Paper speed: 1 cm/s. QRS duration is 65 ms at both time points. (B, top) Representative examples of Poincaré plots of the left ventricular (LV) monophasic action potential duration (MAPD) from the same dog with and without potassium pre-treatment at baseline (green) and after administration of 1.0 mg/kg sertindole (brown). (B, bottom) Composite data of the LV MAPD and the short-term variability (STV)LV from 7 dogs presented. *p < 0.05 (2-way analysis of variance); No K+, no potassium pre-treatment; K+, elevated plasma [K+]. (C) Poincaré plots, RR intervals, and STVRR of the same beats measured in B. Potassium, but not sertindole, increases the variability of the RR interval despite that elevated [K+] prevents sertindole-induced increase of STVLV.
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