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Figure 2 (A) Baseline and on-treatment (8 weeks) microvascular responses to acetylcholine (ACh) in the 16 women randomized to metformin (p = 0.0003, 2-way repeated measures analysis of variance [ANOVA]). (B) Baseline and on-treatment (8 weeks) microvascular responses to ACh in the 17 women randomized to placebo (p = 0.50, 2-way repeated measures ANOVA). (C) Baseline and on-treatment (8 weeks) microvascular responses to sodium nitroprusside (SNP) in the 16 women randomized to metformin (p = 0.46, 2-way repeated measures ANOVA). (D) Baseline and on-treatment (8 weeks) microvascular responses to SNP in the 17 women randomized to placebo (p = 0.95, 2-way repeated measures ANOVA).
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