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Figure 1 Strategies for treatment of myocardial infarction using biomaterials. To date, 3 different biomaterial approaches are being examined for treatment of myocardial infarction. Polymer meshes can be sutured around the heart for use as a left ventricular (LV) restraint (a) to preserve LV geometry. In vitro engineered tissue involves culturing cells on a biomaterial scaffold in vitro and then implanting the tissue onto the epicardial surface (b). In situ engineered tissue can be achieved by injecting a biomaterial alone (d), or using an injectable scaffold as a delivery vehicle for cells (c) or therapeutic agents such as genes or proteins (e).
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