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Figure 2 Effects of stem cell mobilization by G-CSF on neointimal hyperplasia after stenting, BMS: EXPRESS versus PES: TAXUS. (A and B) Histology of the iliac artery 60 days after BMS and PES deployment with or without stem cell mobilization by G-CSF. Stem cell mobilization by G-CSF significantly aggravated neointimal formation at BMS. The trend of such aggravation of neointimal formation was also observed at PES. Note that neointimal growth at PES even after G-CSF treatment was less than that at BMS after placebo. Arrowheads indicate internal elastic lamina; BMS, in the placebo group (albumin); PES, in the placebo group; G-BMS, BMS in the G-CSF group; G-PES, PES in the G-CSF group. (C) Digital image-analyzed morphometry of neointimal thickness was presented as mean ± SD BMS versus PES, p < 0.001; BMS versus G-BMS, p = 0.015; BMS versus G-PES, p = 0.036; and PES versus G-PES, p = 0.36. (D) Neointimal area: BMS versus PES, p < 0.001; BMS versus G-BMS, p = 0.053; BMS versus G-PES, p = 0.015; and PES versus G-PES, p = 0.505 by analysis of variance with Bonferroni’s correction. Abbreviations as in Figure 1.
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