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Figure 5 (A) Platelet-derived growth factor receptor (PDGFR)- and PDGFR-ß inhibition decreased collagen deposition in the infarcted myocardium. (A) After 7 days of reperfusion, Sirius red staining identified a well-organized collagen network in the infarcted heart from animals treated with control rat immunoglobulin (Ig)G. (B) Mice treated with anti–PDGFR- antibody (APA5) had attenuated collagen deposition in the infarcted myocardium. (C) Mice injected with anti–PDGFR-ß antibody (APB5) showed decreased and disorganized collagen deposition. Note the presence of dilated vessels (arrows). (D) Quantitative assessment of collagen deposition in the infarcted heart (*p < 0.05 vs. IgG control group). Magnification 400x.
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