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Figure 6 (A) Effect of thrombopoietin receptor (TPOR)-Fc chimera on the priming activity induced by plasma from patients with unstable angina (UA) on adenosine 5'-diphosphate (ADP)-induced monocyte-platelet aggregation (left) and platelet P-selectin expression (right) in whole blood. (B) Effect of TPOR-Fc chimera on the priming activity induced by plasma from patients with UA on epinephrine (EPI)-induced monocyte-platelet aggregation (left) and platelet P-selectin expression (right) in whole blood. Pretreatment of plasma sample with the TPOR-Fc chimera significantly reduced the percentages of ADP- or EPI-induced monocyte-platelet binding and platelet P-selectin expression observed after preincubation of whole blood from healthy adult donors with plasma from UA patients. Analysis of variance with Newman-Keuls multicomparison test was performed.
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