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Figure 6 Positron emission tomography (PET)–computed tomographic (CT) imaging of integrin expression. Shown are representative short-axis slices through injection sites receiving adenovirus carrying the HSV1-sr39tk reporter gene together with the VEGF121 gene (AdTk-VEGF) in 2 different animals which underwent a repeat PET-CT session at 3 (top, animal 5; Table 1) or 9 (bottom, animal 7; Table 1) days after adenovirus injection. CT images (multislice computed tomography [MSCT], left) depict location of titanium clip markings of injection sites (yellow arrows). Middle left shows fusion of MSCT with PET images of the perfusion tracer [13N]ammonia at rest. PET perfusion images (middle right) show significant accumulation of [13N]ammonia at the site of AdTk-VEGF injection. PET images of [18F]-galacto-RGD (right) show no accumulation at vector injection sites.
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