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Figure 3 (A) In vivo single-photon emission computed tomography (SPECT) imaging of In-111–labeled stem cells implanted in the infarcted rat heart; a dual-energy window detects simultaneously Tc-99m (pseudo-colored in yellow) and In-111 (blue) signals; the SPECT images were coregistered on a magnetic resonance image (grey) (reprinted from Shen et al. [113] with kind permission of Springer Science and Business Media). (B) Autoradiographs of heart slices obtained after In-111 and Feridex double-labeled stem cells were implanted in the infarcted heart of a rat; (C and D) Prussian blue staining of iron for localization of stem cells (reprinted by permission of the Society of Nuclear Medicine from Zhou et al. [109)]. (E and F) Homing of In-111–labeled bone marrow–derived mesenchymal stem cells to infarcted heart (dog) after intravenous injection at day 1 (E), day 2 (F) and day 7 (G) by SPECT imaging is shown. For each panel, sagittal (left) and coronal (right) view of fused SPECT (color) and CT (grey) images are shown. Initial retention of cells in the lung is indicated by strong In-111 signal in the lung (reprinted from Kraitchman et al. [110] with permission). LV = left ventricle; RV = right ventricle.
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