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Figure 5 Immunohistochemical stainings of myeloid dendritic cell (mDC) precursors (BDCA-1), plasmacytoid dendritic cell (pDC) precursors (BDCA-2), tissue-resident DC (fascin), and the DC-specific chemokine MIP-3 in the plaque shoulder (PS) and in the lipid core (LC) of carotid plaques (magnification, x150). (A) Representative example of an atherosclerotic plaque with stable morphology (thick fibrous cap, small lipid core) of an asymptomatic patient. (B) Representative example of an atherosclerotic plaque with a vulnerable morphology (thin fibrous cap, huge lipid core) of a patient with a transient ischemic attack (TIA). Note the remarkably higher frequency of mDC, tissue-resident DC, and MIP-3 in the vulnerable plaque of the patient with TIA compared with the stable plaque of the asymptomatic patient. Only few pDC precursors were observed in both types of plaques.
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